Pubblicazioni scientifiche

La ricerca a sostegno del rivoluzionario metodo sviluppato e brevettato da Studium Genetics per la valutazione del rischio del paziente di sviluppare un carcinoma orale a cellule squamose (OSCC) è stata pubblicata sulle principali riviste internazionali specializzate a revisione paritaria.

  1. Gissi, D. B., Suàrez-Fernandez, C., Rossi, R., Vitali, F., Marzi Manfroni, A., Gabusi, A., Morandi, L., Balbi, T., Montebugnoli, L., Foschini, M. P., & Tarsitano, A. (2024). Direct healthcare costs of oral cancer: A retrospective study from a tertiary care center. Journal of Cranio-Maxillofacial Surgery. https://doi.org/10.1016/j.jcms.2024.03.002

  2. Gissi DB, Rossi R, Lenzi J, Tarsitano A, Gabusi A, Balbi T, Montebugnoli L, Marchetti C, Foschini MP, Morandi L. Thirteen-gene DNA methylation analysis of oral brushing samples: A potential surveillance tool for periodic monitoring of treated patients with oral cancer. Head Neck 2024 Jan 3. https://doi.org/10.1002/hed.27621

  3. Morandi L, Gissi D, Tarsitano A, Asioli S, Gabusi A, Marchetti C, Montebugnoli L, Foschini MP. CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel. Clin Epigenetics 2017 Aug 15; 9:85. https://doi.org/10.1186/s13148-017-0386-7. 

  4. Gissi DB, Morandi L, Colella G, De Luca R, Campisi G, Mauceri R, Romeo U, Tenore G, Mignogna MD, Adamo D, Oteri G, Marcianò A, Vescovi P, Meleti M, Serpico R, Di Stasio D, Pentenero M, Santarelli A, Bianchi A, Crimi S, Marchetti C, Tarsitano A, Foschini MP, Montebugnoli L. Clinical validation of 13-gene DNA methylation analysis in oral brushing samples for detection of oral carcinoma: Italian multicenter study. Head Neck, 2021 May; 43(5):1563-1573. https://doi.org/10.1002/hed.26624

  5. Gissi DB, Fabbri VP, Gabusi A, Lenzi J, Morandi L, Melotti S, Asioli S, Tarsitano A, Balbi T, Marchetti C, Montebugnoli L. Pre-Operative Evaluation of DNA Methylation Profile in Oral Squamous Cell Carcinoma Can Predict Tumor Aggressive Potential. Int J Mol Sci. 2020 Sep 14; 21(18):6691. https://doi.org/10.3390/ijms21186691

  6. Gissi DB, Tarsitano A, Gabusi A, Rossi R, Attardo G, Lenzi J, Marchetti C, Montebugnoli L, Foschini MP, Morandi L. 13-gene DNA Methylation Analysis from Oral Brushing: A Promising Non Invasive Tool in the Follow-up of Oral Cancer Patients. J Clin Med 2019 Dec 2; 8(12):2107. https://doi.org/10.3390/jcm8122107

  7. Rossi R, Gissi DB, Gabusi A, Fabbri VP, Balbi T, Tarsitano A, Morandi L. A 13-Gene DNA Methylation Analysis Using Oral Brushing Specimens as an Indicator of Oral Cancer Risk: A Descriptive Case Report. 2022 Diagnostics 2022, 12(2), 284. DOI: 10.3390/diagnostics12020284

  8. Gabusi A, Gissi DB, Grillini S, Stefanini M, Tarsitano A, Marchetti C, Foschini MP, Montebugnoli L, Morandi L. Shared epigenetic alterations between oral cancer and periodontitis: A preliminary study. Oral Dis. 2022 May 14. DOI: https://doi.org/10.1111/odi.14251

  9. Morandi L, Gissi D, Tarsitano A, Asioli S, Monti V, Del Corso G, Marchetti C, Montebugnoli L, Foschini MP. DNA methylation analysis by bisulfite next-generation sequencing for early detection of oral squamous cell carcinoma and high-grade squamous intraepithelial lesion from oral brushing. J Craniomaxillofac Surg 2015 Oct; 43(8):1494-500. doi: https://doi.org/10.1016/j.jcms.2015.07.028

  10. Gissi DB, Gabusi A, Tarsitano A, Asioli S, Rossi R, Marchetti C, Montebugnoli L, Foschini MP, Morandi L. Application of a non-invasive oral brushing procedure based on bisulfite sequencing of a 13-gene panel to study high-risk OSCC patients. Cancer Biomark 2020; 28(4):499-510. DOI: 10.3233/CBM-190422

  11. Gissi DB, Gabusi A, Tarsitano A, Rossi R, Balbi T, Morandi L. Multi-Region Sequence Analysis of a Pregnancy-Related Oral Squamous Cell Carcinoma Exhibiting Low-Level Aggressive Behavior. Int J Surg Pathol . 2020 Apr; 28(2):188-195. DOI https://doi.org/10.1177/1066896919876058

  12. Gissi DB, Morandi L, Gabusi A, Tarsitano A, Marchetti C, Cura F, Palmieri A, Montebugnoli L, Asioli S, Foschini MP, Scapoli L. A Noninvasive Test for MicroRNA Expression in Oral Squamous Cell Carcinoma. Int J Mol Sci 2018 Jun 16; 19(6):1789. DOI: 10.3390/ijms19061789

  13. Morandi L, Sabattini S, Renzi A, Rigillo A, Bettini G, Dervas E, Schauer A, Morandi M, Gissi DB, Tarsitano A, Evangelisti S, Tonon C. An Evolutionary Cancer Epigenetic Approach Revealed DNA Hypermethylation of Ultra-Conserved Non-Coding Elements in Squamous Cell Carcinoma of Different Mammalian Species. Cells. 2020 Sep 13; 9(9):2092. DOI: https://doi.org/10.3390/cells9092092

  14. Renzi A, Morandi L, Bellei E, Marconato L, Rigillo A, Aralla M, Lenzi J, Bettini G, Tinto D, Sabattini S. Validation of oral brushing as a non-invasive technique for the identification of feline oral squamous cell carcinoma by DNA methylation and TP53 mutation analysis. Vet Comp Oncol 2021 Sep; 19(3):501-509. DOI: https://doi.org/10.1111/vco.12688

  15. Renzi A, Morandi L, Lenzi J, Rigillo A, Bettini G, Bellei E, Giacomini A, Tinto D, Sabattini S. Analysis of DNA methylation and TP53 mutational status for differentiating feline oral squamous cell carcinoma from non-neoplastic mucosa: A preliminary study. Vet Comp Oncol 2020 Dec; 18(4):825-837. DOI: https://doi.org/10.1111/vco.12624 

  16. Renzi A, De Bonis P, Morandi L, Lenzi J, Tinto D, Rigillo A, Bettini G, Bellei E, Sabattini S. Prevalence of p53 dysregulations in feline oral squamous cell carcinoma and non-neoplastic oral mucosa. PLoS One 2019 Apr 18; 14(4):e0215621. DOI: 10.1371/journal.pone.0215621